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Description
Biotinylated Fc γ RIIIb/CD16b(NA2) His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms Fc gamma RIIIB, CD16b (NA2), FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3 Accession AAA35881. 1 Amino Acid Sequence Gly17 Ser200, with C terminal His and Avi Tag Expression System HEK293 Molecular Weight 40 52kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0.
Product Specification
| Species | Human |
| Synonyms | Fc gamma RIIIB, CD16b (NA2), FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3 |
| Accession | AAA35881.1 |
| Amino Acid Sequence | Gly17-Ser200, with C-terminal His and Avi Tag |
| Expression System | HEK293 |
| Molecular Weight | 40-52kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Yue Wang, Jianming Wu, Robert Newton, Nooshin S. Bahaie, Chunmei Long, Bruce Walcheck: ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1833, Issue 3, March 2013, Pages 680-685. |
Background
Receptors for the Fc region of IgG (Fc gamma R) are members of the Ig superfamily. Based on their genetic organization and molecular structure, three classes of human Fc γ Rs can be identified: RI (CD64), RII (CD32), and RIII (CD16), which produce a variety of isoforms. Fc γ RI is a high-affinity receptor that binds monomeric IgG. Both Fc γ RII and RIII are low-affinity receptors that bind IgG as immune complexes. Two genes have been identified for human Fc γ RIII, A and B, which encode a transmembrane receptor and a glycosylphosphatidylinositol (GPI) anchored protein, respectively. Three allelic variants of Fc γ RIIIB, NA-1, NA-2, and SH were present. CD16 inhibits a variety of cellular functions such as B cell activation/proliferation and mast cell degranulation, cannot mediate antibody-dependent cytotoxicity and phagocytosis, acts as a trap for peripheral circulating immune complexes, and binds IgG complexes but does not activate neutrophils. CD16 regulates the inflammatory process by interacting with CR3 and CR4 and inducing IL-6 and IL-8 production by monocytes.
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