Multifokale Retinopathie 2 (CMR2)
SKU: 9703214075

Multifokale Retinopathie 2 (CMR2)

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Description

Multifokale Retinopathie 2 (CMR2)Die canine multifokale Retinopathie (CMR2) ist eine autosomal rezessive genetische Augenerkrankung, die der Best'schen Makuladystrophie beim Menschen hnelt. Eine verursachende Mutation im BEST1 Gen erzeugt ein vorzeitiges Stop Codon, was zu einem nicht funktionalen Protein fhrt, das fr die ordnungsgeme Bildung des Pigmentepithels in der Netzhaut verantwortlich ist. Typische klinische Befunde umfassen multifokale Bereiche von Netzhauterhebungen, die zu

Die canine multifokale Retinopathie (CMR2) ist eine autosomal rezessive genetische Augenerkrankung, die der Best'schen Makuladystrophie beim Menschen ähnelt. Eine verursachende Mutation im BEST1-Gen erzeugt ein vorzeitiges Stop-Codon, was zu einem nicht funktionalen Protein führt, das für die ordnungsgemäße Bildung des Pigmentepithels in der Netzhaut verantwortlich ist. Typische klinische Befunde umfassen multifokale Bereiche von Netzhauterhebungen, die zu multifokalen Bereichen von äußerer Netzhautatrophie fortschreiten. Bei betroffenen Tieren entwickelt sich die Krankheit vor dem Alter von 4 Monaten und kann langsam fortschreiten. Einige betroffene Tiere zeigen erst später im Leben Symptome.

Vererbung: autosomal rezessiv

Mutation: BEST1-Gen

Gentest: Die für den Test verwendete Methode ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. Der Test kann in jedem Alter durchgeführt werden.

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SKU: 9703214075

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4.6 ★★★★★
Based on 2337 reviews
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Product Reviews
D
Verified Purchase
Danyelle
Boise, US
★★★★★ 4
Fun with a late blooming omega
Format: Kindle
I like this book. The story is fun, cute, and sexy. There's just a little drama, some excellent, steamy scenes, and a fairly good relationship building storyline. I especially like how all the main characters are a bit older than the usual 20 somethings I tend to see in this kind of book. Having said that, I wish there were more descriptions of the places, as well as the food in the fancy restaurant. I enjoyed the cocktails at the club, so I missed that kind of detail when Gray took Madison on a dinner date. I also wish there had been more interaction between Lucas and Madison, and Lucas and Rian. It felt a bit lopsided, with a focus on Rian, Madison, and Gray. I wish it had been proofread - there are a lot of typos, but nothing too distracting.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 12, 2022
J
Verified Purchase
Jennifer G
San Leandro, US
★★★★★ 3
Madison Deserved Better
Format: Kindle
Madison was a beta...except she wasn't any longer. She was a late presenting Omega. And she was struggling. She was tall and thin, not tiny and curvy. She was opinionated. She was everything an Omega was not. After suffering through her first heat, her friends took her to Ardor, a club where Omegas came to safely find Alphas. She's not expecting much but then she connects with a sexy beta. And when she meets his Alphas, they set her body on fire. Maybe, she's found her no-strings-attached heat pack. Maybe, she's found something more. I could not connect with the characters in this book, so their story never resonated with me. And there was no love story; there was sex. Grey made it clear from the beginning that he had a true love and it was his beta boy, Rian. He went so far as to reassure Rian “Say the word, I’ll never touch her again. Lucas can put the babies in her. I only need you, beta boy”. So, Madison was there for babies, no emotions needed. Nice. No, thank you. I want the Omega to be the center of their world, not an incubator. Lucas and Rian weren't any better. After her heat, they let her leave. Not one of them made her feel valued. No one gave her a reason to stay or even offered a cuddle. And the sex didn't even come across as mind-blowing. Madison deserved better.
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Reviewed in the United States on March 11, 2025
O
Verified Purchase
Oregon BookWorm
Belleville, US
★★★★★ 5
No breakup, very sweet, instalove
Format: Kindle
Omegaverse and doesn't disappoint! Sweet guys, newly Omega FMC. The boyfriends are boyfriends. What's not to love? No angst, no breakup.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 23, 2025
F
Verified Purchase
ForTheLOVEofBooks
New York, US
★★★★★ 4
Pretty Darn Good
Format: Kindle
So I’ve been on a omega kick and this definitely hit the spot. Madison was frustrating at times with how she acted towards Lucas, Gray, and Rian. It was like she said towards the end, she didn’t believe she deserved nice things. It would have been nice to hear from her best friends again. They kind of were there in the beginning and the gone except for mention of text messages received from them. I feel like her friends would have been great help in encouraging Madison to go with the pack and never give Brent another chance because he was toxic. I loved Rian. His personality was awesome. His humor. His ability to make Madison comfortable whenever she was feeling overwhelmed. And the fact he fell for her and she fell for him first. They are cute together. I do feel like Lucas was the odd man out though. Like Lucas didn’t develop as much of a relationship with Madison. I would have really liked to see more development in the relationship between them. It was also the same with him and Rian. There is really no relationship displayed. Most of the relationship being displayed is between Rian and Gray. Nevertheless, I loved reading about the dynamic that came to fruition during the entirety of this story. Madison finally got her happiness. And Brent finally got punched in the face. Everyone got exactly what they deserve.
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Reviewed in the United States on September 6, 2022
E
Verified Purchase
ediebegonia
Massapequa, US
★★★★★ 3
Pack's Promise was okay but not great
Format: Kindle
Pack's Promise was okay but not great. I won't recommend it to anyone that I know. PRO: * Very likable characters * Lots of steamy scenes that are written very well * The spelling and grammar are good * The punctuation is good with the exception of using hyphens instead of commas. Lots of hyphens. Lots and lots of hyphens. CON: * Almost no interactions with any characters outside of Madison and the pack * Nearly no plot. They meet, get together for a heat, agree to make it permanent, done * Quite a few typos such as extraneous words, missing words and words out of order THINGS TO KNOW: * More steamy scenes than storytelling * A lot of MM & MMM, some MFMM during heat
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Reviewed in the United States on January 5, 2023

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