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Description
Prekallikrein DefizienzPrekallikreinmangel ist eine ungewhnliche autosomal rezessive Erkrankung. Es handelt sich um eine hmostatische Erkrankung, die durch einen Mangel an dem Gerinnungsfaktor Prekallikrein (PK) gekennzeichnet ist. PK ist ein Blutprotein, das am Blutgerinnungsprozess beteiligt ist, sodass betroffene Hunde eine verlngerte aktivierte partielle Thromboplastinzeit aufweisen. Die Krankheit ist normalerweise asymptomatisch, ohne Anzeichen eines hmostatischen
Prekallikreinmangel ist eine ungewöhnliche autosomal-rezessive Erkrankung. Es handelt sich um eine hämostatische Erkrankung, die durch einen Mangel an dem Gerinnungsfaktor Prekallikrein (PK) gekennzeichnet ist. PK ist ein Blutprotein, das am Blutgerinnungsprozess beteiligt ist, sodass betroffene Hunde eine verlängerte aktivierte partielle Thromboplastinzeit aufweisen. Die Krankheit ist normalerweise asymptomatisch, ohne Anzeichen eines hämostatischen Defekts in Abwesenheit anderer Mängel an Blutgerinnungsfaktoren, was die Entdeckung erschwert.
Vererbung: autosomal rezessiv
Mutation: KLKB1-Gen
Gentest: Die verwendete Methode für genetische Tests ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.
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4.1 ★★★★★
Based on 1155 reviews
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Product Reviews
★★★★★ 5
Safe, Lightweight, Hydrating – Perfect for sensitive, super oily, acne-prone skin
Size: 1.85 Fl Oz (Pack of 1), Size: 1.85 Fl Oz (Pack of 1)
I care most about the ingredients, and this Madagascar Centella Ampule is excellent — all the ingredients are safe, with no potential harm to your health, and it’s Yuka app approved with a 100/100 safety score. I feel confident using it on my sensitive, super oily, acne-prone skin.
It’s super lightweight, absorbs quickly, and is not sticky at all — after applying, you just feel comfortable hydration. Even after a few hours, my skin doesn’t get oily, unlike some other serums I’ve used. It helps calm my skin and restore the barrier, which is perfect for my skin type. Even when I have acne wounds, it doesn’t irritate or sting — it’s extremely gentle. For sensitive, super oily, acne-prone skin like mine, it works wonderfully.
Living in Utah, one of the driest states in the U.S., this serum keeps my skin hydrated even in very dry conditions, and a little goes a long way — 1–1.5 drops cover my face and neck. Using more can make my skin slightly oily, so just the right amount works perfectly. For someone with dry skin, results may differ, but for my skin type, it works beautifully.
It’s also super affordable, and I’m glad it’s available on Amazon, with occasional great deals at Costco. I appreciate that it’s accessible at this price because this serum helps my skin a lot — very gentle on my acne-prone, sensitive, super oily skin.
The serum is super easy to apply with the dropper, which keeps other things from getting into the bottle — it’s perfect for easy, hygienic application. Just note that the bottle is glass, so be careful — it may break if dropped.
I’ve only been using it for three weeks, but it’s already a staple. I currently use one bottle, and the other two are extra for long-term use, especially since I got them on a great deal. This is now my main hydration serum, and I’ll update after longer use if needed.
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Reviewed in the United States on January 19, 2026
★★★★★ 5
Very impressed
Size: 3.38 Fl Oz (Pack of 1)
Really impressed by this serum! Got this to soothe my skin after overdoing it with too many different “actives”, and it gently and quickly got rid of redness and flaking, restored my skin barrier, and left my skin so moisturized and supple that I didn’t even feel like I needed lotion or cream afterwards. And it’s a GENEROUSLY sized glass bottle, too! I will definitely be trying other products from this brand!
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Best skincare product ever
Size: 3.38 Fl Oz (Pack of 1)
This ampoule is THE BEST THING EVER. I’ve been in the skincare industry since 1996 and I’ve never used a product that works as well as this. I have sensitive oily skin and it has a lot of redness. After the first use the redness was completely gone and the hydration was noticeable. Do not pass on this stuff! Highly recommend it for anyone wanting immediate hydration. It’s thin and isn’t sticky or tacky. It feels like I don’t have anything on my face but the benefits are definitely noticeable.
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Reviewed in the United States on April 18, 2026
★★★★★ 4
Good product, but requires consistent use
Size: 1.85 Fl Oz (Pack of 1), Size: 1.85 Fl Oz (Pack of 1)
I’ve been using this centella ampoule for a while now, and overall I like it. The texture is lightweight, absorbs quickly, and leaves the skin feeling hydrated and soothed. It’s especially nice for sensitive or irritated skin.
However, one important thing to note is that the results are not immediate. In my experience, you start seeing improvements with consistent, long-term use rather than overnight. If you’re patient and use it daily, it can definitely help improve your skin’s appearance.
Overall, it’s a good product, but it requires consistency to see full results.
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Reviewed in the United States on April 17, 2026
★★★★★ 5
Keeping this in my skincare regimen for the long-haul
Size: 3.38 Fl Oz (Pack of 1)
No matter what skin type you are, you should have this in your lineup. I have larger pores - so sebaceous filaments & clogging. On top of the oiliness of my skin, I have more oily hair as well. But, I get dry patches like crazy. So it’s not easy to find products that meet all of my needs or are universal - it’s usually an “either or” situation. & I end up buying things for my drier days as well as products for my oily days instead of just one set of products. This is one that work well no matter what. There’s more than you’d expect based on the photos - the bottle is bigger. A little goes a long way. It’s very gentle. Great for barrier repair. Great for redness/irritation. A little goes a long way, but it can also be used more than once without being overwhelming. It’s great as a base for other serums/moisturizers, morning or night. It feels really good - clean & light (but not “light” as in ineffective, it still pulls its weight). Must have for anyone looking for trendy Korean glass-skin skincare - she’s one that will get you there without needing to invest in random “viral” products.
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Reviewed in the United States on May 10, 2026