SKU: 28246855931

Von Willebrand Erkrankung I (vWDI)

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Description

Von Willebrand Erkrankung I (vWDI)Die von Willebrand Krankheit (vWD) ist die hufigste erbliche Blutungsstrung bei Hunden sowie beim Menschen. vWD wird durch partielle oder vollstndige Abwesenheit des von Willebrand Faktors (vWF) oder dessen Funktionsunfhigkeit aufgrund struktureller Anomalien verursacht. Der von Willebrand Faktor ist ein multimeres Plasmaprotein, das eine wesentliche Rolle bei der Hmostase spielt, der Reaktion des Krpers auf Blutgefschden und Blutungen. Das vWF

Die von-Willebrand-Krankheit (vWD) ist die häufigste erbliche Blutungsstörung bei Hunden sowie beim Menschen. vWD wird durch partielle oder vollständige Abwesenheit des von-Willebrand-Faktors (vWF) oder dessen Funktionsunfähigkeit aufgrund struktureller Anomalien verursacht. Der von-Willebrand-Faktor ist ein multimeres Plasmaprotein, das eine wesentliche Rolle bei der Hämostase spielt, der Reaktion des Körpers auf Blutgefäßschäden und Blutungen. Das vWF-Protein ist erforderlich für die normale Thrombozytenadhäsion an Stellen von Gefäßverletzungen und fördert die Thrombozytenaggregation. Darüber hinaus stabilisiert es auch den Blutgerinnungsfaktor VIII (FVIII). Charakteristische klinische Anzeichen der vWD sind: schnelles Auftreten von verlängerten und anhaltenden Blutungen an Stellen geringfügiger Hautverletzungen und Venepunkturen, spontane Schleimhautblutungen aus der Nasenhöhle, dem Darm und dem Zahnfleisch, postoperative und posttraumatische Verletzungen... Trotz der Bedeutung des vWF bei der Blutgerinnung ist die partielle oder vollständige Abwesenheit von vWF im Blut nicht immer tödlich, und die vWD kann über Jahre unbemerkt bleiben. Betroffene Individuen können leichte, moderate oder schwere Blutungen erleben, da die vWD eine genetisch und klinisch heterogene Erkrankung ist. Bei Hunden treten drei Typen der von-Willebrand-Krankheit auf, und verschiedene Mutationen im VWF-Gen sind verantwortlich für die quantitativen und qualitativen Eigenschaften des vWF, die die Grundlage für die Unterteilung der vWD in vWD Typ I (partielle Abwesenheit von vWF), II (nicht funktionales vWF) und III (vollständige Abwesenheit von vWF) bilden.

Die von-Willebrand-Krankheit Typ I (vWD I), die bei vielen Hunderassen vorkommt, ist die häufigste Form der vWD, die bei den meisten Säugetieren gefunden wird. vWD Typ I ist gekennzeichnet durch eine mild bis moderate Blutungsneigung aufgrund eines konstanten Mangels an ansonsten vollständig funktionalem Plasma-vWF, und obwohl sie im Allgemeinen weniger schwerwiegend ist als die Typen II und III, können ernsthafte Blutungen auftreten.

Die vWD wird allgemein durch einen ELISA-Test diagnostiziert, der das vWF-Antigen nachweist und nur angewendet wird, wenn Blutungen auftreten. Darüber hinaus ist es aufgrund der zeitlichen Schwankungen in der Menge an Plasma-vWF immer nicht möglich, den genetischen Status der Tiere zu bestimmen, daher ist der ELISA-Test kein zuverlässiger Test. Die einzige zuverlässige Methode zur Bestimmung des Genotyps für vWD ist ein genetischer Diagnosetest, der die Variantenallele des VWD-Gens bestimmt, die zwischen klaren, Trägern und betroffenen Hunden genau unterscheiden.

Vererbung: autosomal rezessiv

Mutation: VWF Gen

Gentest: Die verwendete Methode zum Testen ist extrem genau und ermöglicht eine vollständige Differenzierung zwischen betroffenen Tieren, Trägern und gesunden Hunden. Tests können in jedem Alter durchgeführt werden.

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SKU: 28246855931

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4.1 ★★★★★
Based on 623 reviews
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Verified Purchase
Denise Boyd
West Palm Beach, US
★★★★★ 4
Great toy but if your dog is an aggressive chewer, please think twice.
Color: Crinkle Chicken (Brown), Size: Large
I received this on May 23rd and on June 8th, after playing with this thing every day, our recently acquired 36 lb dog finally ripped it open and got out all the plastic and the squeaky part. Lily Belle will miss you, chicken. Lily loooooved this toy! She'd toss it in the air, chew on it, pull it with her teeth etc. but as much as she loved it, we won't replace it. It's just not durable enough for her. If your dog is an aggressive chewer, you might want to try a different toy. I hate that this lasted just a smidge over two weeks because Lily seemed to truly enjoy this toy. RIP, squeaky chicken!
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Reviewed in the United States on June 9, 2026
S
Verified Purchase
supermommy
Boise, US
★★★★★ 5
Best Dog Bone
Flavor Name: Beef, Size: Large
This is one of the best bones I've seen and I have always lived with dogs. The shape makes it so ergonomic for the dog, both of mine hold the bone down with both paws then chew the part standing up. One of my dogs was able to enjoy this while wearing a cone after surgery, supporting her natural behavior and keeping her busy. These are great for our 11 month old puppy because he was struggling to figure out how to brace the bone without it rubbing his paws, so was bracing on furniture and getting in trouble. Now he can hold the T part easily and doesn't need to use other objects he shouldn't chew by accident. They are durable, too. I got these about 2 months ago and they are barely worn with a rotty/pit/Shepard mix male puppy. If you know dogs, you know that means this is a solid durable bone! I will for sure keep these on hand for years as they are a preferred chew in my house!
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Reviewed in the United States on May 1, 2026
B
Verified Purchase
Baibhav Bhattarai
Charlottesville, US
★★★★★ 5
Doggy Delight
Flavor Name: Beef, Size: Medium
Ever felt like your dog’s chew toys are on the fritz, ending up shredded like yesterday’s sandwich? The SPOT Bam-bones PLUS T Bone is here to save the day, offering a durable and tasty solution for aggressive chewers and teething puppies alike. These bamboo fiber and nylon chews are like the super-tough treats your dog dreams of, providing hours of gnawing joy without the splintering mess. My bulldog, who treats his chew toys like they’re part of a survival game, has found his perfect match in these T Bones. The beef flavor is irresistible, making them a favorite among picky pups and ensuring they stay engaged without turning into edible confetti. The 6-inch size is perfect for keeping his jaws busy without overwhelming his mouth – a win-win for both of us. The non-splintering design is a blessing, preventing any painful encounters with broken chews and keeping our home safe from unexpected trips to the vet. Plus, the durable construction means these chews last longer than my patience during a doggy tantrum – and that’s saying something! However, the T Bones can sometimes feel like they’re too tough, requiring a bit of extra chewing to fully enjoy – turning every chew session into a mini workout for your dog’s jaws. Additionally, the price point is slightly higher than standard chews, but the durability and quality make it worth every penny. Overall, the SPOT Bam-bones PLUS T Bone is a fantastic choice for dog owners looking to provide their pets with a long-lasting and enjoyable chew experience. It’s tough, tasty, and built to withstand even the most enthusiastic chewers. A solid 5-star rating for its durability and flavor, with a tiny star lost to its occasional toughness challenges.
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Reviewed in the United States on October 23, 2024
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Verified Purchase
Amazon Customer
Bozeman, US
★★★★★ 5
The Ultimate Solution for Power Chewers!
Flavor Name: Beef, Size: Medium
I have a Pitbull mix who can usually destroy "tough" toys in minutes, but the Bam-Bones Plus is a total game-changer. The bamboo and nylon blend is incredibly dense; it satisfies that natural urge to chew without splintering like real wood or falling apart like rubber. It wears down slowly and safely, giving my dog weeks of use rather than minutes. ​Smart, Functional Design ​The T-bone shape is brilliant because of the "paw-grip" base—it makes it so easy for my dog to hold it steady while she works on it. I’ve also noticed her teeth looking much cleaner since we started using this, as the raised textures act like a natural toothbrush. Plus, the infused beef scent keeps her interested much longer than a plain nylon bone ever could. ​Final Verdict ​This is a must-have for any owner of a large or aggressive chewer. It’s safe, long-lasting, and provides excellent mental stimulation.
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Reviewed in the United States on April 16, 2026
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Verified Purchase
Lisa D.
Alexandria, US
★★★★★ 4
Fantastic Durable Chew Toy That My Dog Loves!
Flavor Name: Beef, Size: Medium
Absolutely thrilled with this dog chew toy! It’s extremely tough and durable — perfect for aggressive chewers and keeps my pup entertained for a long time. The bamboo fiber and nylon design feels sturdy yet gentle on the teeth, and it even helps with dental hygiene by massaging gums while he chews. My dog goes crazy for this bone and it lasts way longer than other chew toys we’ve tried. Great quality and great value — highly recommend for any dog
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Reviewed in the United States on January 17, 2026

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