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Description
human pgp vesicle kit hek293P Glykoproteine MDR1 Assay 100 Reaktionen Das Human Pgp Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient P Glykoprotein (P gp MDR1 ABCB1) berexprimieren. P gp ist einer der klinisch relevantesten Efflux Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut Hirn Schranke exprimiert. Das Kit ist konform mit den FDA (2017) und EMA (2013) DDI Leitlinien. Hergestellt von Cell4Pharma.
P-Glykoproteine / MDR1 Assay | 100 Reaktionen
Das Human Pgp Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient P-Glykoprotein (P-gp / MDR1 / ABCB1) überexprimieren. P-gp ist einer der klinisch relevantesten Efflux-Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut-Hirn-Schranke exprimiert. Das Kit ist konform mit den FDA (2017)- und EMA (2013)-DDI-Leitlinien.
Hergestellt von Cell4Pharma. Eine Variante mit dem neuartigen fluoreszenten FluoPgp-Substrat ist ebenfalls erhältlich (C4PVK011).
Exklusiv im DACH-Raum über SeamlessBio erhältlich.
Transporter-Profil
Name: P-gp, P-Glykoprotein, MDR1, Multidrug Resistance Protein 1, Permeabilitätsglykoprotein, ABCB1, ATP-bindende Kassette Unterfamilie B Mitglied 1
Gen: ABCB1
ATP/AMP-Ratio: >5 (garantiert)
Gewebsexpression: Darm, Leber, Niere, Blut-Hirn-Schranke, viele Tumorzellen
Bekannte Substrate: Convallatoxin, Digoxin, N-Methyl-Chinidin (NMQ), Colchicin, Tacrolimus, Chinidin, Etoposid, Doxorubicin
Lagerbestand: Human-Pgp. Ebenfalls verfügbar: Maus- und Ratten-Pgp
Kit Inhalt (100 Reaktionen)
-
- AMP-ATP Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Hinweis: C4PVK011 enthält zusätzlich das neuartige FluoPgp Fluoreszenzsubstrat für fluoreszenzbasierte Detektion ohne Radiolabeling.
Anwendungen
- P-gp-Substratidentifikation und Efflux-Charakterisierung
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Studien zur Multiresistenz (MDR)-Mechanistik
- In-vitro-Bewertung der Blut-Hirn-Schranken-Penetration
- Inhibitionsstudien und IC50-Bestimmung
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
P-Glykoprotein (ABCB1) ist ein primärer Transporter in den FDA (2017)- und EMA (2013)-DDI-Leitlinien. Die Bewertung des P gp-Substrat-und Inhibitorstatus ist für alle neuen Molekülentitäten (NMEs) mit signifikanter oraler oder systemischer Exposition in der klinischen Entwicklung erforderlich.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle) Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel Variante mit FluoPgp-Substrat: C4PVK011
Lagerung: –80 °C
Verwandte Produkte
- Human Pgp Vesicle Kit + FluoPgp Substrat (C4PVK011)
- Fluoreszenz-Detektionsvariante, kein Radiolabeling erforderlich
- Human BCRP Vesicle Kit (C4PVK006) – für parallele BCRP-Efflux-Bewertung
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle
- ciPTEC-OAT1 Assay-Ready Cells – exprimieren funktionelles endogenes P-gp (ABCB1) für zellbasierte Bestätigungsstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Datasheet
Publikation
Gozalpour E, Wittgen HG, van den Heuvel JJ, et al. Interaction of digitalis-like compounds with p-glycoprotein. Toxicol Sci. 2013,131(2):502-11. doi: 10.1093/toxsci/kfs307
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4.7 ★★★★★
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★★★★★ 5
Amazing
I only buy this stuff from now on! Works amazingly well and is a great exfoliant!
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Reviewed in the United States on April 21, 2026
★★★★★ 5
It works!! Worth every penny!
I'm a type 2 diabetic and insulin resistant, so I normally have a dark ring on the back of my neck. I've tried everything. This stuff with the first treatment removed it. It's gone! Worth every penny!! The before photo is a year old. However it looked like that prior to the treatment.
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Reviewed in the United States on March 1, 2026
★★★★★ 5
Love it
Love this
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Reviewed in the United States on April 5, 2026
★★★★★ 5
Great sunscreen
Size: 2.82 Fl Oz (Pack of 1)
No white filmy cast. Soothing and easy to apply.
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Reviewed in the United States on June 6, 2026
★★★★★ 5
Beef Tallow Sunscreen
That dry, stretched sensation that I sometimes get from using other sunscreens was not something that I experienced with this one. On the contrary, I had the impression that my skin remained supple and pleasant throughout the morning. I used it prior to going about my errands, having a drive, going for a stroll outdoors, and spending time at the park. To my satisfaction, I did not feel the need to quickly apply another moisturizing lotion on top of the one I was using in order to restore the natural feel of my skin. Simply said, it made it simpler for me to utilize on a daily basis. When I wore it for a longer period of time, I also paid attention to how it felt on my face. Even though I wore it on a number of days when the temperature was high, I did not experience any discomfort as the day progressed. Despite the fact that I was aware that I was wearing sunscreen, I did not feel any discomfort or want to wash my face straight away with it. Because I am quite particular about the products that I use on my face, I found that to be really helpful. In addition to having a sunscreen that is dependable, I want it to be something that I can really endure for a considerable amount of time.
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Reviewed in the United States on June 9, 2026
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